Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Oct;52(10):669-73.
doi: 10.4111/kju.2011.52.10.669. Epub 2011 Oct 19.

Prognostic factors and clinical outcomes of urological soft tissue sarcomas

Geonseok Lee  1 , Seo Yeon Lee, Seongil Seo, Seongsoo Jeon, Hyunmoo Lee, Hanyong Choi, Byong Chang Jeong
Affiliations

Prognostic factors and clinical outcomes of urological soft tissue sarcomas

Geonseok Lee et al. Korean J Urol. 2011 Oct.

Abstract

Purpose: The purpose of this study was to elucidate prognostic factors for survival and clinical outcomes of rological soft tissue sarcomas (STSs).

Materials and methods: This was a retrospective review of the medical records of 48 patients with urological STS treated from January 1982 to July 2009. Demographic and pathological characteristics were compared. Patients' demographics, clinico-pathological parameters, overall survival, and the factors expected to predict survival, such as sex, age at diagnosis, primary organ, surgical resection, metastasis, and mass size, were analyzed. We evaluated differences in survival on the basis of histological subtype by Kaplan-Meier analysis and multivariate Cox proportional hazards regression.

Results: The study included 34 males (70.8%) and 14 females (29.1%). The mean age at diagnosis was 47.1 years (range, 3 to 80). The most common site was the retroperitoneum (n=16), followed by the kidney (n=12), prostate (n=10), bladder (n=7), ureter (n=1), and paratesticular region (n=1). Nineteen patients (39.5%) had other organ metastases at diagnosis. The most common subtypes of sarcoma were leiomyosarcoma (50%), rhabdomyosarcoma (18.7%), and liposarcoma (8%). The remaining 11 cases had other histological subtypes (22.9%). Mean tumor size was 9.5 cm (range, 2.2 to 24). Thirty-three patients (68.7%) underwent surgical resection. The overall survival rate at 5 years was 51.4%. In the univariate and multivariate analysis, surgical resection, primary tumor site, and metastasis at diagnosis remained significant predictors of prognosis. Patients with retroperitoneal sarcoma had a higher overall survival rate by 5 years compared with patients with other organ sarcoma.

Conclusions: The overall survival rate at 5 years was 51.4%. Surgical resection, primary tumor site, and metastasis at diagnosis remained significant predictors of prognosis.

Keywords: Factor; Outcome; Sarcoma; Surgery; Survival.

PubMed Disclaimer

Conflict of interest statement

The authors have nothing to disclose.

Figures

FIG. 1
FIG. 1
Kaplan-Meier analysis of disease specific survival in all patients.
FIG. 2
FIG. 2
Kaplan-Meier analysis of overall survival according to presence vs. abscence of metastasis at diagnosis.
FIG. 3
FIG. 3
Kaplan-Meier analysis of overall survival according to surgical resection or not.
FIG. 4
FIG. 4
Kaplan-Meier analysis of overall survival according to primary organ.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, et al. Cancer statistics, 2005. CA Cancer J Clin. 2005;55:10–30. - PubMed
    1. Russo P, Brady MS, Conlon K, Hajdu SI, Fair WR, Herr HW, et al. Adult urological sarcoma. J Urol. 1992;147:1032–1036. - PubMed
    1. Stojadinovic A, Leung DH, Allen P, Lewis JJ, Jaques DP, Brennan MF. Primary adult soft tissue sarcoma: time-dependent influence of prognostic variables. J Clin Oncol. 2002;20:4344–4352. - PubMed
    1. Izumi K, Mizokami A, Sugimoto K, Narimoto K, Miyagi T, Maeda Y, et al. Role of surgical resection in adult urological soft tissue sarcoma: 25-year experience. Urol Int. 2010;84:309–314. - PubMed
    1. Mondaini N, Palli D, Saieva C, Nesi G, Franchi A, Ponchietti R, et al. Clinical characteristics and overall survival in genitourinary sarcomas treated with curative intent: a multicenter study. Eur Urol. 2005;47:468–473. - PubMed