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. 2011 Oct;41(5):242-7.
doi: 10.5051/jpis.2011.41.5.242. Epub 2011 Oct 31.

The effect of fibronectin-coated implant on canine osseointegration

Sungtae Kim  1 , Woo-Chun Myung, Jung-Seok Lee, Jae-Kook Cha, Ui-Won Jung, Hyeong-Cheol Yang, In-Seop Lee, Seong-Ho Choi
Affiliations

The effect of fibronectin-coated implant on canine osseointegration

Sungtae Kim et al. J Periodontal Implant Sci. 2011 Oct.

Abstract

Purpose: The purpose of this study was to characterize the osseointegration of the fibronectin-coated implant surface.

Methods: Sand-blasted, large-grit, acid-etched (SLA) surface implants, with or without a thin calcium phosphate and fibronectin coating, were placed in edentulous mandibles of dogs 8 weeks after extraction. All dogs were sacrificed forhistological and histomorphometric evaluation after 4- and 8-week healing periods.

Results: All types of implants were clinically stable without any mobility. Although the bone-to-implant contact and bone density of the SLA implants coated with calcium phosphate (CaP)/fibronectin were lower than the uncoated SLA implants, there were no significant differences between the uncoated SLA surface group and the SLA surface coated with CaP/fibronectin group.

Conclusions: Within the limits of this study, SLA surfaces coated with CaP/fibronectin were shown to have comparable bone-to-implant contact and bone density to uncoated SLA surfaces.

Keywords: Biocompatible coated materials; Bone density; Calcium phosphate; Dental implants; Fibronectins.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
Histologic view of the fibronectin-coated sandblasted, large-grit, acid-etched group at 4 weeks (Goldner's trichrome staining, ×40). Osteoid matrix (arrow) and newly formed mineralized bone in the interthread space were observed.
Figure 2
Figure 2
Histologic view of the sandblasted, large-grit, acid-etched group at 4 weeks (Goldner's trichrome staining, ×40). A thin lining of newly formed bone was observed on the implant surface. Marrow space (arrow) near the osteoid matrix was observed.
Figure 3
Figure 3
Histologic view of the fibronectin-coated sandblasted, large-grit, acid-etched group at 8 weeks (Goldner's trichrome staining, ×40). Osseointegration of each implant was confirmed. Newly formed mineralized bone in the interthread space was observed.
Figure 4
Figure 4
Histologic view of the sandblasted, large-grit, acid-etched group at 8 weeks (Goldner's trichrome staining, ×40). The newly formed bone in the interthread space was in close contact with implant surface without any gaps or dense fibrous connective tissue. No apical epithelial migration was found. No inflammatory cell infiltrate was present around the implants.
See this image and copyright information in PMC

References

    1. Dohan Ehrenfest DM, Coelho PG, Kang BS, Sul YT, Albrektsson T. Classification of osseointegrated implant surfaces: materials, chemistry and topography. Trends Biotechnol. 2010;28:198–206. - PubMed
    1. Atieh MA, Payne AG, Duncan WJ, de Silva RK, Cullinan MP. Immediate placement or immediate restoration/loading of single implants for molar tooth replacement: a systematic review and meta-analysis. Int J Oral Maxillofac Implants. 2010;25:401–415. - PubMed
    1. Bornstein MM, Hart CN, Halbritter SA, Morton D, Buser D. Early loading of nonsubmerged titanium implants with a chemically modified sand-blasted and acid-etched surface: 6-month results of a prospective case series study in the posterior mandible focusing on peri-implant crestal bone changes and implant stability quotient (ISQ) values. Clin Implant Dent Relat Res. 2009;11:338–347. - PubMed
    1. Morton D, Bornstein MM, Wittneben JG, Martin WC, Ruskin JD, Hart CN, et al. Early loading after 21 days of healing of nonsubmerged titanium implants with a chemically modified sandblasted and acid-etched surface: two-year results of a prospective two-center study. Clin Implant Dent Relat Res. 2010;12:9–17. - PubMed
    1. Oates TW, Valderrama P, Bischof M, Nedir R, Jones A, Simpson J, et al. Enhanced implant stability with a chemically modified SLA surface: a randomized pilot study. Int J Oral Maxillofac Implants. 2007;22:755–760. - PubMed