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Clinical Trial
. 2011 Dec;6(12):2135-7.
doi: 10.1097/JTO.0b013e3182307e06.

Asymptomatic profound sinus bradycardia (heart rate ≤45) in non-small cell lung cancer patients treated with crizotinib

Sai-Hong Ignatius Ou  1 , Michele Azada, Joni Dy, Jonathan A Stiber
Affiliations
Free article
Clinical Trial

Asymptomatic profound sinus bradycardia (heart rate ≤45) in non-small cell lung cancer patients treated with crizotinib

Sai-Hong Ignatius Ou et al. J Thorac Oncol. 2011 Dec.
Free article

Abstract

Crizotinib, a dual MET/ALK inhibitor, is now in advanced clinical development for the treatment of anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). We have observed several patients who developed profound but asymptomatic sinus bradycardia (HR ≤45) during the course of crizotinib treatment. Herein, we describe the clinical characteristics of three separate patients enrolled in the A8081001 trial (NCT00585195) who developed asymptomatic profound sinus bradycardia with their accompanying electrocardiogram tracings.

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