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. 2011 Aug 1;67(Pt 8):o1952-3.
doi: 10.1107/S1600536811026560. Epub 2011 Jul 9.

Clostebol acetate

Elisabetta Maccaroni  1 , Andrea Mele, Renato Del Rosso, Luciana Malpezzi
Affiliations

Clostebol acetate

Elisabetta Maccaroni et al. Acta Crystallogr Sect E Struct Rep Online. .

Abstract

The title compound, C(21)H(29)ClO(3) [systematic name (8R,9S,10R,13S,14S,17S)-4-chloro-3-oxoandrost-4-en-17β-yl acetate], is a 4-chloro derivative of testosterone, used as an anabolic androgenic agent or applied topically in ophthalmological and dermatological treatments. The absolute configurations at positions 8, 9, 10, 13, 14 and 17 were established by refinement of the Flack parameter as R, S, R, S, S, and S, respectively. Rings B and C of the steroid ring system adopt chair conformations, ring A has a half-chair conformation, while ring D is in a C(13) envelope conformation. Ring B and C, and C and D are trans fused. In the crystal, molecules are linked by a weak C-H⋯O interaction.

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Figures

Fig. 1.
Fig. 1.
Molecular structure of clostebol acetate with the atomic numbering. Displacement ellipsoids are drawn at the 30% probability level.
Fig. 2.
Fig. 2.
Crystal packing of clostebol acetate viewed along the a axis. Intermolecular C—H···O weak interactions are shown by dashed lines.
Fig. 3.
Fig. 3.
Crystal packing of clostebol acetate viewed along the b axis.
See this image and copyright information in PMC

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