Hypoadiponectinemia in obese subjects with type II diabetes: A close association with central obesity indices

Abstract

Background: Adiponectin is an adipocyte secreted protein with important biological functions Hypoadiponectinemia is associated with obesity, insulin resistance, and type II diabetes This study aimed to evaluate serum adiponectin level in obese subjects with type II diabetes and its correlation with metabolic parameters

Methods: This cross-sectional study was performed on 40 obese subjects with type II diabetes and 40 non-diabetic obese control subjects Fasting lipid profile was measured by the enzymatic methods The NycoCard HbA1c protocol was used to measure HbAlc The Serum adiponectin, insulin and glucose levels were measured using an enzyme immunoassay and glucose oxidase methods respectively

Results: Type II diabetes was associated with hypoadiponectinemia, in both men and women Serum adiponectin level in non-diabetic subjects (6.44 ± 2.47 μg/ml) was significantly higher than diabetics (4.55 ± 1.88 μg/ml) Furthermore, serum adiponectin concentration in females was significantly higher than males in non-diabetics (7.18 ± 2.68 vs 5.61 ± 0.57) and diabetic groups (5.18 ± 2.08 vs 3.99 ± 1.5) There was a negative and significant correlation between serum adiponectin level with waist (r = -0.451, p = 0.003), waist to hip ratio (r = -0.404, p = 0.01) and BMI (r = - 0.322, p = 0.042) and a positive correlation with HDL (r = 0.337, p = 0.034) in non-diabetic group In diabetic group, there was only found a negative correlation between adiponectin and waist size (r = -0.317, p = 0.046)

Conclusions: Obesity and type II diabetes are associated with low serum adiponectin concentration.

Keywords: Adiponectin; BMI; Obese; Type II diabetes.

Figure 1

A. Relationship between serum adiponectin levels and HDL-C. Fasting serum adiponectin levels of normal women (filled triangles) upper dashed line andnormal men (empty triangles), lower dashed line and total subjects middle solid line, were plotted against HDL-C. The "r" values represent correlation coefficient in linear regression analysis. B. Relationship between serum adiponectin levels and waist to hip ratio in all subjects. C. Relationship between serum adiponectin levels and waist circumference in women.

Figure 2

Serum Adiponectin levels normalized to BMI in the all subjects. Adiponectin levels were represented for men (empty bar) and for women (filled bar). Adiponectin levels were significantly reduced in well (p=0.02) and poorly controlled diabetic compared to control group, (p<00001). Among women, adiponectin levels were significantly reduced in poorly controlled diabetic compared to control women (^*p=0.010). Among men adiponectin levels normalized to BMI were significantly reduced in poorly controlled diabetic compared to control men (^**p=0.001). “in all the subjects”-“level” “(p = 0.001)”