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Review
. 2011 Nov;59 Suppl 2(0 2):S256-61.
doi: 10.1111/j.1532-5415.2011.03702.x.

Biomarkers for delirium--a review

Babar A Khan  1 , Mohammed Zawahiri, Noll L Campbell, Malaz A Boustani
Affiliations
Review

Biomarkers for delirium--a review

Babar A Khan et al. J Am Geriatr Soc. 2011 Nov.

Abstract

To improve delirium recognition and care, numerous serum biomarkers have been investigated as potential tools for risk stratification, diagnosis, monitoring, and prognostication of delirium. The literature was reviewed, and no evidence was found to support the clinical use of any delirium biomarker, although certain biomarkers such as S-100 beta and insulin-like growth factor-1 and inflammatory markers have shown some promising results that need to be evaluated in future studies with appropriate sample size, prospective designs, and in a more-generalizable population.

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Conflict of interest statement

Conflict of Interest: There are no conflicts of interest for the authors of this manuscript.

Figures

Figure 1
Figure 1
Complex interplay between inflammatory mediators and cholinergic system in delirium pathogenesis. IGF = insoluble growth factor; APOE = apolipoprotein E; CRP = C-reactive protein; SAA = Serum anticholinergic activity; IL = interleukin; NSE = neuro-specific enolase.
Figure 2
Figure 2
Search strategy.
See this image and copyright information in PMC

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