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. 2012 Jan;134(1):76-82.
doi: 10.1016/j.schres.2011.10.015. Epub 2011 Nov 16.

The MATRICS Consensus Cognitive Battery (MCCB): clinical and cognitive correlates

Sharon M August  1 , Jacqueline N Kiwanuka, Robert P McMahon, James M Gold
Affiliations

The MATRICS Consensus Cognitive Battery (MCCB): clinical and cognitive correlates

Sharon M August et al. Schizophr Res. 2012 Jan.

Abstract

The purpose of this study was to examine the cognitive and clinical correlates of the MATRICS Consensus Cognitive Battery (MCCB) which was originally developed to be an endpoint for cognitive enhancement clinical trials. In a sample of 117 people with schizophrenia and 77 healthy control participants we found the following: a) the MCCB was highly sensitive to the type and level of impairment typically observed in schizophrenia, b) the MCCB composite score was highly correlated with WASI Estimated Full Scale IQ score, c) that the MCCB domain scores were generally moderately-highly intercorrelated, d) that MCCB performance was minimally related to clinical symptom type and severity, and e) the MCCB is sensitive to employment status with better performance in employed vs. unemployed patients. These data support the validity of the MCCB as a sensitive measure of cognitive impairment in schizophrenia and suggest that MCCB performance is relevant for functional outcome. The data also suggest that the MCCB domain scores may offer limited resolution on discrete cognitive functions.

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Conflict of interest statement

Conflict of interest: JG receives royalty payments from the BACS and RM provides consultant services to Amgem. SA and JK have no conflicts to report.

Figures

Figure 1
Figure 1
Figures 1a and 1b. Relationship of Estimated Full Scale IQ and MCCB Overall Composite Score
Figure 2
Figure 2. MCCB Overall Composite Score Distributions
MATRICS overall composite score distributions for healthy controls (black bars) and patients (white bars)
Figure 3
Figure 3. MCCB Domain Mean T Score Comparisons
Note: ProcSpeed- Processing Speed; AttnVig- Attention Vigilance; WorkMem – Working Memory; VerbLern – Verbal Learning; VisLearn – Visual Learning; ProbSolv – Reasoning and Problem Solving; SocCog – Social Cognition; Composite – Overall Composite Score
Figure 4
Figure 4. MCCB Cognitive Domain Scores vs. Vocational Performance
Note: ProcSpeed- Processing Speed; AttnVig- Attention Vigilance; WorkMem – Working Memory; VerbLern – Verbal Learning; VisLearn – Visual Learning; ProbSolv – Reasoning and Problem Solving; SocCog – Social Cognition; Composite – Overall Composite Score
See this image and copyright information in PMC

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