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Comment
. 2011 Nov 15;20(5):555-6.
doi: 10.1016/j.ccr.2011.10.028.

Power cut: inhibiting mitochondrial translation to target leukemia

Marcus Järås  1 , Benjamin L Ebert
Affiliations
Free article
Comment

Power cut: inhibiting mitochondrial translation to target leukemia

Marcus Järås et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Skrtic et al. demonstrate that inhibition of mitochondrial ribosomes with tigecycline, a known antimicrobial, selectively kills leukemia cells. This finding highlights the metabolic susceptibility of leukemia cells to mitochondrial translational inhibition and identifies a compound with significant efficacy in an in vivo preclinical model.

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  • Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia.
    Skrtić M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z, Hurren R, Jitkova Y, Gronda M, Maclean N, Lai CK, Eberhard Y, Bartoszko J, Spagnuolo P, Rutledge AC, Datti A, Ketela T, Moffat J, Robinson BH, Cameron JH, Wrana J, Eaves CJ, Minden MD, Wang JC, Dick JE, Humphries K, Nislow C, Giaever G, Schimmer AD. Skrtić M, et al. Cancer Cell. 2011 Nov 15;20(5):674-88. doi: 10.1016/j.ccr.2011.10.015. Cancer Cell. 2011. PMID: 22094260 Free PMC article.

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