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Comment
. 2011 Nov 15;20(5):559-61.
doi: 10.1016/j.ccr.2011.10.027.

Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma

Marc R Mansour  1 , A Thomas Look
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Free article
Comment

Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma

Marc R Mansour et al. Cancer Cell. .
Free article

Abstract

In a recent paper in Cell, Oricchio et al. identify EPHA7 as a tumor suppressor gene residing in the 6q-deleted region in follicular lymphoma. A truncated EPHA7(TR) isoform is secreted by normal B cells, inhibits EPHA2 signaling, and, as a secreted tumor suppressor protein, has potential as a targeted therapeutic polypeptide.

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  • The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma.
    Oricchio E, Nanjangud G, Wolfe AL, Schatz JH, Mavrakis KJ, Jiang M, Liu X, Bruno J, Heguy A, Olshen AB, Socci ND, Teruya-Feldstein J, Weis-Garcia F, Tam W, Shaknovich R, Melnick A, Himanen JP, Chaganti RS, Wendel HG. Oricchio E, et al. Cell. 2011 Oct 28;147(3):554-64. doi: 10.1016/j.cell.2011.09.035. Cell. 2011. PMID: 22036564 Free PMC article.

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