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. 2012 Feb;142(2):201-8.
doi: 10.1016/j.clim.2011.10.005. Epub 2011 Oct 30.

Increased risk of asthma and atopic dermatitis in perinatally HIV-infected children and adolescents

George K Siberry  1 , Erin Leister, Denise L Jacobson, Samuel B Foster, George R Seage 3rd, Steven E Lipshultz, Mary E Paul, Murli Purswani, Andrew A Colin, Gwendolyn Scott, William T Shearer
Affiliations

Increased risk of asthma and atopic dermatitis in perinatally HIV-infected children and adolescents

George K Siberry et al. Clin Immunol. 2012 Feb.

Abstract

The incidence of asthma and atopic dermatitis (AD) was evaluated in HIV-infected (n = 451) compared to HIV-exposed (n = 227) but uninfected (HEU) children and adolescents by abstraction from clinical charts. Asthma was more common in HIV-infected compared to HEU children by clinical diagnosis (25% vs. 20%, p = 0.101), by asthma medication use, (31% vs. 22%, p = 0.012), and by clinical diagnosis and/or medication use, (34% vs. 25%, p = 0.012). HIV-infected children had a greater risk of asthma compared to HEU children (HR = 1.37, 95% CI: 1.01 to 1.86). AD was more common in HIV-infected than HEU children (20% vs. 12%, p = 0.009)) and children with AD were more likely to have asthma in both cohorts (41% vs. 29%, p = 0.010). HIV-infected children and adolescents in this study had an increased incidence of asthma and AD, a finding critical for millions of HIV-infected children worldwide.

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Figures

Figure 1
Figure 1
Time to first occurrence of asthma, defined as diagnosis, medication use, or both from Cox regression analysis. Curves represent the estimated probability of remaining asthma free by HIV status. The estimated cumulative incidence of asthma at 5, 10, and 15 years of age are presented in the body of the graph as is the p-value for the hazard ratio
See this image and copyright information in PMC

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