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Editorial
. 2011 Dec;31(12):2775-6.
doi: 10.1161/ATVBAHA.111.238865.

We can do it together: PAR1/PAR2 heterodimer signaling in VSMCs

Rafal Pawlinski, Michael Holinstat
Editorial

We can do it together: PAR1/PAR2 heterodimer signaling in VSMCs

Rafal Pawlinski et al. Arterioscler Thromb Vasc Biol. 2011 Dec.
No abstract available

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Figures

Figure
Figure
Protease-activated receptor (PAR)1 and PAR2 are functionally, and likely physically, interacting in the vascular smooth muscle cells (VSMCs). PAR1 can be activated either by cleavage of the amino terminal by thrombin (revealing the tethered ligand) or by direct binding of the PAR1 agonist, P1pal-13, to the third intracellular loop of PAR1. PAR1 activation requires the presence of PAR2. Activation of PAR1 in the presence of PAR2 results in VSMCs hyperplasia as well as dedifferentiation of the VSMCs, both of which play significant roles in the thickening of the vessel wall eventually resulting in restenosis.
See this image and copyright information in PMC

Comment on

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