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Editorial
. 2011 Dec;31(12):2777-8.
doi: 10.1161/ATVBAHA.111.237610.

Calcific aortic valve disease: cellular origins of valve calcification

Editorial

Calcific aortic valve disease: cellular origins of valve calcification

Nalini M Rajamannan. Arterioscler Thromb Vasc Biol. 2011 Dec.
No abstract available

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Figures

Figure 1.
Figure 1.
Demonstrates the Calcific Aortic Valve Disease: Cellular Origins of Valves Calcification and the mechanisms of osteogensis in these cell types. Panel A: The potential cellular phenotypes for mesenchymal derived cells, Panel B: The two different cell origins for valve calcification: the COP cell and the native interstitial cell both contributing to the hypothesis of osteogenesis in calcific aortic valve disease.

Comment on

References

    1. Roberts WC, Ko JM, Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation. Circulation, 2005. 111: p. 920–5. - PubMed
    1. Egan KP, Kim J, Mohler EM, Pignolo RJ, Role for Circulating Oteogenic Precursor (COP) cells in Aortic Valvular Disease, ATVB, In Press - PMC - PubMed
    1. Rajamannan NM, Subramaniam M, Rickard D, Stock SR, Donovan J, Springett M, Orszulak T, Fullerton DA, Tajik AJ, Bonow RO, Spelsberg T, Human aortic valve calcification is associated with an osteoblast phenotype. Circulation, 2003. 107: p. 2181–4. - PMC - PubMed
    1. Mohler ER 3rd, Gannon F, Reynolds C, Zimmerman R, Keane MG, Kaplan FS, Bone formation and inflammation in cardiac valves. Circulation, 2001. 103: p. 1522–8. - PubMed
    1. Shao JS, Cheng SL, Pingsterhaus JM, Charlton-Kachigian N, Loewy AP, Towler DA, Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals. J Clin Invest, 2005. 115: p. 1210–20. - PMC - PubMed