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. 2011 Oct;27(4):522-6.
doi: 10.4103/0970-9185.86599.

Effect of one minimum alveolar concentration sevoflurane with and without fentanyl on hemodynamic response to laryngoscopy and tracheal intubation

Anwar Hoda  1 , Fauzia A Khan
Affiliations

Effect of one minimum alveolar concentration sevoflurane with and without fentanyl on hemodynamic response to laryngoscopy and tracheal intubation

Anwar Hoda et al. J Anaesthesiol Clin Pharmacol. 2011 Oct.

Abstract

Background: Drug combinations can be used for optimum obtundation of the hemodynamic response to tracheal intubation. The objective of this trial was to compare the hemodynamic response to laryngoscopy and tracheal intubation after administration of 2 μg/kg fentanyl bolus or a placebo with 2% end tidal sevoflurane at induction of anesthesia.

Materials and methods: A total of 70 surgical patients of either gender, age 18-45 years were selected for this double blind, randomized, placebo controlled trial, with 35 in each group. All patients received a standardized induction with thiopentone, atracurium, and an end tidal concentration of 1 minimum alveolar concentration (MAC) sevoflurane. Heart rate and noninvasive blood pressure were compared to the baseline post induction and for seven minutes post intubation. Some adverse events were noted.

Results: The maximum heart rate response was significantly less in the sevoflurane fentanyl group (15% vs. 22%). Significant difference between groups was observed in the systolic blood pressure at six minutes post intubation. Hemodynamic adverse events recorded were similar.

Conclusion: Addition of 2 μg fentanyl bolus to 1 MAC sevoflurane anesthesia at induction attenuated the hemodynamic response to a maximum of 15% above baseline values.

Keywords: Anesthetics; hemodynamic response; inhalational; intubation; sevoflurane; tracheal.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Comparison of heart rate (mean ± SD) between sevoflurane alone (•) and sevoflurane/fentanyl group (O). *indicates significant difference from baseline; †indicates significant difference in heart rate between two groups
Figure 2
Figure 2
Comparison of systolic blood pressure (mean ± SD) between sevoflurane alone (•) and sevoflurane/fentanyl group (O). *indicates significant difference from baseline; †indicates significant difference in systolic blood pressure between two groups
Figure 3
Figure 3
Comparison of diastolic blood pressure (mean ± SD) between sevoflurane alone (•) and sevoflurane/fentanyl group (O). *indicates significant difference from baseline; †indicates significant difference in diastolic blood pressure between two groups
Figure 4
Figure 4
Comparison of mean blood pressure (mean ± SD) between sevoflurane alone (•) and sevoflurane/fentanyl group (O). *indicates significant difference from baseline; †indicates significant difference in mean blood pressure between two groups
See this image and copyright information in PMC

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