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. 2010:2:211-8.
doi: 10.2147/HIV.S11977. Epub 2010 Oct 29.

Atherosclerosis: pathogenesis and increased occurrence in individuals with HIV and Mycobacterium tuberculosis infection

Timothy Guilford  1 , Devin Morris, Dennis Gray, Vishwanath Venketaraman
Affiliations

Atherosclerosis: pathogenesis and increased occurrence in individuals with HIV and Mycobacterium tuberculosis infection

Timothy Guilford et al. HIV AIDS (Auckl). 2010.

Abstract

Atherosclerosis is a leading cause of coronary heart disease and stroke. Since 1981, more than 980,000 cases of AIDS have been reported in the United States. According to the Centers for Disease Control, more than 1 million Americans may be infected with HIV. By killing or damaging CD4+ T cells of the body's immune system, HIV progressively destroys the body's ability to fight infections. People diagnosed with AIDS often suffer from life-threatening diseases caused by opportunistic infections such as tuberculosis. HIV-infected individuals have increased risks for atherosclerosis. This review summarizes the effects of oxidized low density lipoproteins in impairing macrophage functions in individuals with atherosclerosis (with and without HIV infection) thereby enhancing the susceptibility to Mycobacterium tuberculosis infection.

Keywords: AIDS; HIV; Mycobacterium tuberculosis.

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Figures

Figure 1
Figure 1
Receptor mediated uptake of oxidized low density lipoproteins by macrophages resulting in foam cell formation.
Figure 2
Figure 2
Possible causes for decreased intracellular levels of glutathione in individuals with HIV and/or M. tb infection.
See this image and copyright information in PMC

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