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. 2011:2011:167156.
doi: 10.1155/2011/167156. Epub 2011 Jun 28.

Serum metabolic profile in multiple sclerosis patients

Barbara Tavazzi  1 , Anna Paola Batocchi, Angela Maria Amorini, Viviana Nociti, Serafina D'Urso, Salvatore Longo, Stefano Gullotta, Marika Picardi, Giuseppe Lazzarino
Affiliations

Serum metabolic profile in multiple sclerosis patients

Barbara Tavazzi et al. Mult Scler Int. 2011.

Abstract

Multiple sclerosis (MS) is a progressive demyelinating process considered as an autoimmune disease, although the causes of this pathology have not been yet fully established. Similarly to other neurodegenerations, MS is characterized by a series of biochemical changes affecting to different extent neuronal functions; great attention has been given to oxidative/nitrosative stress and to alterations in mitochondrial functions. According to previous data, MS patients show significant changes in the circulating concentrations of different metabolites, although it is still unclear whether uric acid undergoes to decrease, increase, or no change under this pathological condition. In this study, we report the serum metabolic profile in terms of purines, pyrimidines, creatinine, malondialdehyde, ascorbic acid, nitrite, and nitrate in a group of 170 MS patients. The results show increase in circulating uric acid and other oxypurines (hypoxanthine and xanthine), as well as in uridine and β-pseudouridine. The concomitant increase in circulating creatinine, malondialdehyde, nitrite, and nitrate, and decrease in ascorbic acid, demonstrates that MS induces alteration in energy metabolism and in oxidants/antioxidants balance that can be monitored in serum of MS patients.

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Figures

Figure 1
Figure 1
Scatter plot showing the sum of oxypurines (uric acid + hypoxanthine + xanthine) (a) and creatinine (b) recorded in serum of 163 healthy controls and 170 MS patients. Horizontal bars indicate the mean values calculated in the two groups.
Figure 2
Figure 2
Bar graph showing the mean values of creatinine, uric acid, and sum of oxypurines (uric acid + hypoxanthine + xanthine) in the 170 MS patients divided on the basis of the clinical MS subtype. RR: relapsing remitting; SP: secondary progressive; PP: primary progressive. Standard deviations are indicated by vertical bars. Asterisk = significantly different from RR (P < .01).
Figure 3
Figure 3
Scatter plot showing the concentrations of uridine (a) and β-pseudouridine (b) recorded in serum of 163 controls healthy and 170 MS patients. Horizontal bars indicate the mean values calculated in the two groups.
Figure 4
Figure 4
Scatter plot showing the concentrations of MDA (a) and sum of nitrite and nitrate (b) recorded in serum 163 controls healthy and 170 MS patients. Horizontal bars indicate the mean values calculated in the two groups.
Figure 5
Figure 5
Scatter plot showing the concentration of ascorbic acid recorded in serum 163 healthy controls and 170 MS patients. Horizontal bars indicate the mean values calculated in the two groups.
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