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Comment
. 2011 Nov 18;44(4):509-10.
doi: 10.1016/j.molcel.2011.11.002.

Staying alive: defensive strategies in the BCL-2 family playbook

Sean P Cullen  1 , Conor M Henry, Seamus J Martin
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Staying alive: defensive strategies in the BCL-2 family playbook

Sean P Cullen et al. Mol Cell. .
Free article

Abstract

Much debate surrounds how prosurvival members of the BCL-2 family repress opening of the BAX/BAK channel to block apoptosis; in this issue Llambi et al. (2011) identify two modes of apoptosis inhibition that exhibit surprisingly different behavior upon repeat proapoptotic challenges by BH3-only proteins.

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