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Review
. 2012 Jun;9(6):992-5.
doi: 10.1016/j.hrthm.2011.11.024. Epub 2011 Nov 16.

Gap junctions and arrhythmogenic cardiomyopathy

Angeliki Asimaki  1 , Jeffrey E Saffitz
Affiliations
Review

Gap junctions and arrhythmogenic cardiomyopathy

Angeliki Asimaki et al. Heart Rhythm. 2012 Jun.
No abstract available

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Figures

Figure 1
Figure 1
A. 12-lead electrocardiogram at rest from a 7-year-old patient with Naxos disease in the “concealed phase” showing QRS prolongation (to 110 ms) and epsilon waves in leads V1 through V3, and deeply inverted T waves in leads V1 through V3. B. Low magnification sections of left and right ventricles at autopsy showing no evidence of myocardial degeneration or fibrofatty tissue accumulation (trichrome Heidenhain stain). C. Representative confocal images showing loss of immunoreactive Cx43 signal at intercalated disks in the left ventricle of this patient compared with a normal control. D. Immunoblot of Cx43 in left and right ventricular myocardium of this patient showing apparent loss of highly phosphorylated Cx43 (arrows) compared with a normal control. Figure modified from Kaplan et al.
Figure 2
Figure 2
A proposed disease pathway in arrhythmogenic cardiomyopathy showing potential mechanisms of gap junction remodeling
See this image and copyright information in PMC

References

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    1. Saffitz JE. Dependence of electrical coupling on mechanical coupling in cardiac myocytes – insights gained from cardiomyopathies caused by defects in cell-cell communication. Ann NY Acad Sci. 2005;1047:336–344. - PubMed
    1. Kostin S, Hein S, Bauer EP, Schaper J. Spatiotemporal development and distribution of intercellular junctions in adult rat cardiomyocytes in culture. Circ Res. 1999;85:154–167. - PubMed
    1. Saffitz JE, Green KG, Kraft WJ, Schechtman KB, Yamada KA. Effects of diminished expression of connexin43 on gap junction number and size in ventricular myocardium. Am J Physiol (Heart Circ Physio) 2000;278:H1662–H1670. - PubMed

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