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. 2011 Oct;9(7):524-30.
doi: 10.2174/157016211798842062.

The CD4C/HIV(Nef)transgenic model of AIDS

Paul Jolicoeur  1
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The CD4C/HIV(Nef)transgenic model of AIDS

Paul Jolicoeur. Curr HIV Res. 2011 Oct.

Abstract

CD4C/HIVNef Tg mice express HIV-1 Nef in relevant target cells through the regulatory sequences of the human CD4 gene. These mice develop a severe disease showing many characteristics of human AIDS. A summary of the results obtained with these Tg mice is presented.

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