Tiotropium is superior to salmeterol in reducing frequency of exacerbations: but the effect of adding tiotropium to the combination of inhaled corticosteroid and long-acting β(2)-agonist remains unclear

Affiliations

Comment

Rick Hodder. Evid Based Med. 2012 Jun.

. 2012 Jun;17(3):93-5.

doi: 10.1136/ebmed.2011.100206. Epub 2011 Nov 22.

No abstract available

Comment on

Combination inhaled steroid and long-acting beta(2)-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease.
Karner C, Cates CJ. Karner C, et al. Cochrane Database Syst Rev. 2011 Mar 16;(3):CD008532. doi: 10.1002/14651858.CD008532.pub2. Cochrane Database Syst Rev. 2011. Update in: Cochrane Database Syst Rev. 2016 Jun 06;(6):CD008532. doi: 10.1002/14651858.CD008532.pub3. PMID: 21412920 Free PMC article. Updated.
Tiotropium versus salmeterol for the prevention of exacerbations of COPD.
Vogelmeier C, Hederer B, Glaab T, Schmidt H, Rutten-van Mölken MP, Beeh KM, Rabe KF, Fabbri LM; POET-COPD Investigators. Vogelmeier C, et al. N Engl J Med. 2011 Mar 24;364(12):1093-1103. doi: 10.1056/NEJMoa1008378. N Engl J Med. 2011. PMID: 21428765 Clinical Trial.