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. 1990 Jul-Aug;18(4):210-4.
doi: 10.1007/BF01643387.

Cerebrospinal fluid and serum neopterin levels in patients with Lyme neuroborreliosis

L Dotevall  1 , D Fuchs, G Reibnegger, H Wachter, L Hagberg
Affiliations

Cerebrospinal fluid and serum neopterin levels in patients with Lyme neuroborreliosis

L Dotevall et al. Infection. 1990 Jul-Aug.

Abstract

Elevated (greater than 3.0 nmol/l) cerebrospinal fluid neopterin concentrations were observed in 20 of 21 patients with Lyme neuroborreliosis compared with three of 11 control patients with headache, back pain or psychoneurotic disorders. Neopterin concentrations were correlated to mononuclear cell counts and protein concentrations in the cerebrospinal fluid (CSF). Following antibiotic treatment, CSF neopterin levels decreased. Serum neopterin levels were not significantly raised in patients with neuroborreliosis when compared to control subjects. Neopterin levels as well as cell count and protein concentration in the CSF are valuable inflammation markers of disease activity in Lyme neuroborreliosis.

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