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Review
. 2012 Jan;8(1):101-11.
doi: 10.1016/j.hfc.2011.08.003. Epub 2011 Oct 22.

Role of oxidative stress in disease progression in Stage B, a pre-cursor of heart failure

Arvind Bhimaraj  1 , W H Wilson Tang
Affiliations
Review

Role of oxidative stress in disease progression in Stage B, a pre-cursor of heart failure

Arvind Bhimaraj et al. Heart Fail Clin. 2012 Jan.

Abstract

Oxidative stress represents a persistent imbalance between the production and the compensation of reactive oxygen species. Though predominantly found in advanced heart failure, the most frequent "at-risk" condition has been associated with underlying oxidative stress. It is therefore conceivable that timely detection and early intervention to reduce oxidative stress processes provide an opportunity to prevent disease progression to overt heart failure. This article reviews the current understanding of the current evidence of oxidative stress involvement in the pathophysiology of human heart failure and its potential therapeutic interventions in patients with Stage A and B heart failure.

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Figure 1
Figure 1
Role of oxidative stress in progression of heart failure in ischemic heart disease.
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