doi: 10.5607/en.2010.19.3.115.
Epub 2010 Dec 31.
The role of axonopathy in Parkinson's disease
Affiliations
- PMID: 22110350
- PMCID: PMC3214783
- DOI: 10.5607/en.2010.19.3.115
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The role of axonopathy in Parkinson's disease
Exp Neurobiol.
2010 Dec.
Abstract
New genetic and environmental studies of Parkinson's disease have revealed early problems in synaptic function and connectivity indicating that axonal impairment may be an important hallmark in this disorder. Since many studies suggest that axonal dysfunction precedes cell body loss, it is critical to target axons with treatments aimed at preserving "connectivity" as well as to develop and verify "biomarkers" with which to assess disease progression and drug efficacy.
Keywords: MPTP; Wallerian degeneration; axon transport; mitochondria.
Figures
Key features of axonal transport: cargos, tracks and motor proteins.
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