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. 2011 Nov 23:9:103.
doi: 10.1186/1477-7525-9-103.

Measuring health-related quality of life in children with cancer living in Mainland China: feasibility, reliability and validity of the Chinese Mandarin version of PedsQL 4.0 Generic Core Scales and 3.0 Cancer Module

Yi Ji  1 , Siyuan Chen, Kai Li, Nong Xiao, Xue Yang, Shan Zheng, Xianmin Xiao
Affiliations

Measuring health-related quality of life in children with cancer living in Mainland China: feasibility, reliability and validity of the Chinese Mandarin version of PedsQL 4.0 Generic Core Scales and 3.0 Cancer Module

Yi Ji et al. Health Qual Life Outcomes. .

Abstract

Background: The Pediatric Quality of Life Inventory (PedsQL) is widely used instrument to measure pediatric health-related quality of life (HRQOL) for children aged 2 to 18 years. The purpose of the current study was to investigate the feasibility, reliability and validity of the Chinese mandarin version of the PedsQL 4.0 Generic Core Scales and 3.0 Cancer Module in a group of Chinese children with cancer.

Methods: The PedsQL 4.0 Genetic Core Scales and the PedsQL 3.0 Cancer Module were administered to children with cancer (aged 5-18 years) and parents of such children (aged 2-18 years). For comparison, a survey on a demographically group-matched sample of the general population with children (aged 5-18) and parents of children (aged 2-18 years) was conducted with the PedsQL 4.0 Genetic Core Scales.

Result: The minimal mean percentage of missing item responses (except the School Functioning scale) supported the feasibility of the PedsQL 4.0 Generic Core Scales and 3.0 Cancer Module for Chinese children with cancer. Most of the scales showed satisfactory reliability with Cronbach's α of exceeding 0.70, and all scales demonstrated sufficient test-retest reliability. Assessing the clinical validity of the questionnaires, statistically significant difference was found between healthy children and children with cancer, and between children on-treatment versus off-treatment ≥12 months. Positive significant correlations were observed between the scores of the PedsQL 4.0 Generic Core Scale and the PedsQL 3.0 Cancer Module. Exploratory factor analysis demonstrated sufficient factorial validity. Moderate to good agreement was found between child self- and parent proxy-reports.

Conclusion: The findings support the feasibility, reliability and validity of the Chinese Mandarin version of PedsQL 4.0 Generic Core Scales and 3.0 Cancer Module in children with cancer living in mainland China.

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References

    1. Collins JJ, Byrnes ME, Dunkel IJ, Lapin J, Nadel T, Thaler HT, Polyak T, Rapkin B, Portenoy RK. The measurement of symptoms in children with cancer. J Pain Symptom Manage. 2000;19(5):363–377. doi: 10.1016/S0885-3924(00)00127-5. - DOI - PubMed
    1. Erickson JM, Beck SL, Christian BR, Dudley W, Hollen PJ, Albritton KA, Sennett M, Dillon RL, Godder K. Fatigue, sleep-wake disturbances, and quality of life in adolescents receiving chemotherapy. J Pediatr Hematol Oncol. 2011;33(1):e17–e25. doi: 10.1097/MPH.0b013e3181f46a46. - DOI - PubMed
    1. Weintraub N, Rot I, Shoshani N, Pe'Er J, Weintraub M. Participation in daily activities and quality of life in survivors of retinoblastoma. Pediatr Blood Cancer. 2011;56(4):590–594. doi: 10.1002/pbc.22790. - DOI - PubMed
    1. Gurney JG, Tersak JM, Ness KK, Landier W, Matthay KK, Schmidt ML. Hearing loss, quality of life, and academic problems in long-term neuroblastoma survivors: a report from the Children's Oncology Group. Pediatrics. 2007;120(5):e1229–e1236. doi: 10.1542/peds.2007-0178. - DOI - PubMed
    1. Barr RD, Chalmers D, De Pauw S, Furlong W, Weitzman S, Feeny D. Health-related quality of life in survivors of Wilms' tumor and advanced neuroblastoma: aA cross-sectional study. J Clin Oncol. 2000;18(18):3280–3287. - PubMed

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