Review
doi: 10.1111/j.1755-3768.2011.02179.x.
Epub 2011 Nov 23.
Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration
Affiliations
- PMID: 22112056
- DOI: 10.1111/j.1755-3768.2011.02179.x
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Review
Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration
Acta Ophthalmol.
2012 Jun.
Free article
Abstract
Age-related macular degeneration (AMD) is attributed to a complex interaction of genetic and environmental factors. It is characterized by degeneration involving the retinal photoreceptors, retinal pigment epithelium (RPE) and Bruch's membrane, as well as alterations in choroidal capillaries. AMD pathogenesis is strongly associated with chronic oxidative stress and inflammation that ultimately lead to protein damage, aggregation and degeneration of RPE. Specific degenerative findings for AMD are accumulation of intracellular lysosomal lipofuscin and extracellular drusens. In this review, we discuss thoroughly RPE-derived mechanisms in AMD pathology.
© 2011 The Authors. Acta Ophthalmologica © 2011 Acta Ophthalmologica Scandinavica Foundation.
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