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. 2012 Feb 15;19(3-4):311-6.
doi: 10.1016/j.phymed.2011.10.004. Epub 2011 Nov 23.

Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity

M N Nasir  1 , J Abdullah, M Habsah, R I Ghani, G Rammes
Affiliations

Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity

M N Nasir et al. Phytomedicine. .

Abstract

The asiatic acid, a triterpenoids isolated from Centella asiatica was used to delineate its inhibitory effect on acetylcholinesterase (AChE) properties, excitatory post synaptic potential (EPSP) and locomotor activity. This study is consistent with asiatic acid having an effect on AChE, a selective GABA(B) receptor agonist and no sedative effect on locomotor.

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