Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011:4:751-4.
doi: 10.2147/IJGM.S25170. Epub 2011 Oct 31.

Diagnosis of hepatoma using grayscale and Doppler ultrasound in patients with chronic liver disease

Wasim A Memon  1 , Zishan Haider, Mirza Amanullah Beg, Muhammad Idris, Tanveer-Ul-Haq Waseem Akhtar, Sidra Idris
Affiliations

Diagnosis of hepatoma using grayscale and Doppler ultrasound in patients with chronic liver disease

Wasim A Memon et al. Int J Gen Med. 2011.

Abstract

Objective: To determine the diagnostic accuracy of liver ultrasound for the detection of hepatoma in chronic liver disease (CLD) patients by either taking histopathology or serum α-fetoprotein levels or a biphasic computed tomography (CT) scan (whichever is available) as the gold standard.

Study design: Cross-sectional.

Place and duration of study: Radiology Department, The Aga Khan University Hospital, Karachi, Pakistan, from January 2007 to January 2010.

Methods: A total of 239 patients (156 males and 83 females) with clinical suspicion or surveillance of hepatoma in CLD referred to the radiology department for ultrasound evaluation followed by either liver biopsy and histopathology or serum α-fetoprotein level or biphasic CT scan.

Results: The sensitivity of ultrasound for hepatoma detection in CLD was 65%, specificity was 85%, and accuracy was 70%, and positive predictive value and negative predictive value were 92% and 45%, respectively.

Conclusion: Ultrasound is a relatively quick, safe, reasonably accurate, and noninvasive imaging modality for the detection of hepatoma in CLD and can be complemented with clinical assessment of screening high-risk patients.

Keywords: chronic liver disease; hepatoma; radiology; ultrasound.

PubMed Disclaimer

References

    1. Simonetti RG, Camma C, Fiorello F. Hepatocellular carcinoma: a world-wide problem and the major risk factors. Dig Dis Sci. 1991;36:962–972. - PubMed
    1. Morimoto Y, Kubo S, Shuto T, et al. Power Doppler ultrasonographic diagnosis of small hepatocellular carcinomas. Dig Surg. 2002;19:379–387. - PubMed
    1. El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med. 1999;340:745–750. - PubMed
    1. Abdul Mujeeb S, Jamal Q, Khanani R, et al. Prevalence of hepatitis B surface antigen and HCV antibodies in hepatocellular carcinoma cases in Karachi, Pakistan. Trop Doct. 1997;27:45–46. - PubMed
    1. Jamal Q, Jaffarey NA, Aslam SM. A review of unusual liver tumors. J Pak Med Assoc. 1989;39:53–56. - PubMed