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. 2011 Nov 25;11(12):852-63.
doi: 10.1038/nri3108.

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses

Lucy S K Walker  1 , David M Sansom
Affiliations

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses

Lucy S K Walker et al. Nat Rev Immunol. .

Abstract

The T cell protein cytotoxic T lymphocyte antigen 4 (CTLA4) was identified as a crucial negative regulator of the immune system over 15 years ago, but its mechanisms of action are still under debate. It has long been suggested that CTLA4 transmits an inhibitory signal to the cells that express it. However, not all the available data fit with a cell-intrinsic function for CTLA4, and other studies have suggested that CTLA4 functions in a T cell-extrinsic manner. Here, we discuss the data for and against the T cell-intrinsic and -extrinsic functions of CTLA4.

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References

    1. Nature. 2003 May 29;423(6939):506-11 - PubMed
    1. J Immunol. 1998 Jan 1;160(1):95-100 - PubMed
    1. J Exp Med. 2001 Dec 3;194(11):1675-81 - PubMed
    1. Immunity. 2002 Jan;16(1):23-35 - PubMed
    1. Immunity. 2008 Apr;28(4):546-58 - PubMed

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