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Case Reports
. 2012 Feb;50(2):525-7.
doi: 10.1128/JCM.05956-11. Epub 2011 Nov 23.

Emergence of New Delhi metallo-beta-lactamase (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC-2) in South Africa

Adrian J Brink  1 , Jennifer Coetzee, Cornelis G Clay, Sindi Sithole, Guy A Richards, Laurent Poirel, Patrice Nordmann
Affiliations
Case Reports

Emergence of New Delhi metallo-beta-lactamase (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC-2) in South Africa

Adrian J Brink et al. J Clin Microbiol. 2012 Feb.

Abstract

This report documents emergence of New Delhi metallo-beta-lactamase (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC-2) in K. pneumoniae and Enterobacter cloacae in South Africa. NDM-1 producers have not been described in South Africa, and this is the first instance that KPC producers have been identified in Africa. The two patients infected with these carbapenemase-producing bacteria demised.

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References

    1. Carmeli Y, et al. 2010. Controlling the spread of carbapenemase-producing Gram-negatives: therapeutic approach and infection control. Clin. Microbiol. Infect. 16: 102– 111 - PubMed
    1. Clinical and Laboratory Standards Institute 2011. Performance standards for antimicrobial susceptibility testing. 21st informational supplement. CLSI document M100-S21. Clinical and Laboratory Standards Institute, Wayne, PA:
    1. Elliott E, et al. 2006. In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum β-lactamase. Clin. Infect. Dis. 42: e95– e98. - PubMed
    1. European Committee on Antimicrobial Susceptibility Testing 2009. Breakpoint tables for interpretation of MICs and zone diameters, version 1.0, December 2009. European Committee on Antimicrobial Susceptibility Testing, Basel, Switzerland
    1. Grundmann H, et al. 2010. Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts. Euro Surveill. 15: 1– 13 - PubMed

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