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Review
. 2011 Dec;31(4):699-724, x.
doi: 10.1016/j.cll.2011.08.009.

Multiple myeloma: current perspectives

Marilyn L Slovak  1
Affiliations
Review

Multiple myeloma: current perspectives

Marilyn L Slovak. Clin Lab Med. 2011 Dec.

Abstract

Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells characterized by complex genetic aberrations and heterogeneous outcomes. Over the past 25 years, cytogenetic analysis has played a key role in the diagnosis and management of MM. This article reviews the conventional cytogenetics, molecular cytogenetics, and genomic diagnostics of MM and highlights a few recent clinical trials that demonstrate the impact of genetic risk stratification on the treatment of this plasma cell malignancy.

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