Polyoxygenated cyclohexene derivatives from Monanthotaxis congoensis
- PMID: 22119522
- PMCID: PMC3262941
- DOI: 10.1016/j.phytochem.2011.10.014
Polyoxygenated cyclohexene derivatives from Monanthotaxis congoensis
Abstract
A phytochemical investigation of Monanthotaxis congoensis afforded eight polyoxygenated cyclohexenes as well as the known crotepoxide. Structures were determined using NMR, MS, and optical rotation analyses. One compound displayed moderate antiproliferative activity against NCI-H460 and M14 cancer cells.
Copyright © 2011 Elsevier Ltd. All rights reserved.
References
-
- Eldridge GR, Vervoort HC, Lee CM, Cremin PA, Williams CT, Hart SM, Goering MG, O'Neil-Johnson M, Zeng L. High-Throughput Method for the Production and Analysis of Large Natural Product Libraries for Drug Discovery. Anal. Chem. 2002;74:3963–3971. - PubMed
-
- Hollands R, Becher D, Gaudemer A, Polonsky J, Ricroch N. Constituents of Uvaria catocarpa fruits. Structure of senepoxide and seneol. Tetrahedron. 1968;24:1633–1650.
-
- Horeau A. Principle and applications of a new method of determination of configurations termed “by partial resolution.”. Tetrahedron Lett. 1961:506–512.
-
- Hu J-F, Garo E, Yoo H-D, Cremin PA, Zeng L, Goering MG, O'Neil-Johnson M, Eldridge GR. Application of capillary-scale NMR for the structure determination of phytochemicals. Phytochem. Anal. 2005;16:127–133. - PubMed
-
- Kupchan SM, Hemingway RJ, Smith RM. Tumor inhibitors. XLV. Crotepoxide, a novel cyclohexane diepoxide tumor inhibitor from Croton macrostachys. The Journal of Organic Chemistry. 1969;34:3898–3902. - PubMed
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