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. 2012 Mar;99(1-2):183-6.
doi: 10.1016/j.eplepsyres.2011.10.033. Epub 2011 Nov 25.

Superoxide dismutase 2 Val16Ala polymorphism is a risk factor for the valproic acid-related elevation of serum aminotransferases

Junji Saruwatari  1 , Mariko Deguchi, Yuki Yoshimori, Madoka Noai, Shiho Yoshida, Naoki Ogusu, Kentaro Oniki, Shuichi Yoshida, Norio Yasui-Furukori, Sunao Kaneko, Takateru Ishitsu, Kazuko Nakagawa
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Superoxide dismutase 2 Val16Ala polymorphism is a risk factor for the valproic acid-related elevation of serum aminotransferases

Junji Saruwatari et al. Epilepsy Res. 2012 Mar.

Abstract

The association between the superoxide dismutase 2 (SOD2) Val16Ala polymorphism and the serum aminotransferase levels was retrospectively investigated in 207 valproic acid-treated patients with epilepsy. The Val/Val genotype tended to show elevated alanine aminotransferase levels (odds ratio=3.5; P=0.056). In addition, an elevated γ-glutamyltransferase level was associated with the Val/Val genotype (odds ratio=3.1; P=0.022). The SOD2 Val/Val genotype may therefore contribute to a valproic acid-induced elevation in the serum aminotransferase levels.

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