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Review
. 2012 Jan;52(1):108-13.
doi: 10.1016/j.advenzreg.2011.11.001.

Insights into the differences between the A- and B-type nuclear lamins

Stephen A Adam  1 , Robert D Goldman
Affiliations
Review

Insights into the differences between the A- and B-type nuclear lamins

Stephen A Adam et al. Adv Biol Regul. 2012 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Modification of the lamin carboxyl terminus. LA, LB1 and LB2 are synthesized as pre-proteins that are modified by farnesylation of the carboxyl terminus. These steps occurs sequentially beginning with the addition of farnesyl to the cysteine residue of the –CAAX sequence, followed by removal of the three terminal amino acids and carboxymethylation of the cysteine. In LA, an additional 15 amino acids are removed by protease cleavage along with the attached farnesyl moiety. The B-type lamins remain permanently farnesylated.
Figure 2
Figure 2
Separation of the A- and B-type lamin meshworks in the nuclear lamina. Immunofluorescence microscopy of LA and LB1 shows that each lamin forms a meshwork like structure as seen in this view focused on the nuclear surface. An overlay of the two images demonstrates that they are distinct structures with a few points of overlap.
See this image and copyright information in PMC

References

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