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Randomized Controlled Trial
. 2012 Mar;124(3):410-6.
doi: 10.1016/j.ygyno.2011.11.031. Epub 2011 Nov 23.

A randomized parallel-group dietary study for stages II-IV ovarian cancer survivors

Raheem J Paxton  1 , Celia Garcia-Prieto, Maria Berglund, Mike Hernandez, Richard A Hajek, Beverly Handy, Jubilee Brown, Lovell A Jones
Affiliations
Randomized Controlled Trial

A randomized parallel-group dietary study for stages II-IV ovarian cancer survivors

Raheem J Paxton et al. Gynecol Oncol. 2012 Mar.

Abstract

Objective: Few studies have examined the dietary habits of ovarian cancer survivors. Therefore, we conducted a study to assess the feasibility and impact of two dietary interventions for ovarian cancer survivors.

Methods: In this randomized, parallel-group study, 51 women (mean age, 53 years) diagnosed with stages II-IV ovarian cancer were recruited and randomly assigned to a low fat, high fiber (LFHF) diet or a modified National Cancer Institute diet supplemented with a soy-based beverage and encapsulated fruit and vegetable juice concentrates (FVJCs). Changes in clinical measures, serum carotenoid and tocopherol levels, dietary intake, anthropometry, and health-related quality of life (HRQOL) were assessed with paired t-tests.

Results: The recruitment rate was 25%, and the retention rate was 75% at 6 months. At baseline, 28% and 45% of women met guidelines for intake of fiber and of fruits and vegetables, respectively. After 6 months, total serum carotenoid levels and α- and β-carotene concentrations were significantly increased in both groups (P<0.01); however, β-carotene concentrations were increased more in the FVJC group. Serum β-cryptoxanthin levels, fiber intake (+5.2g/day), and daily servings of juice (+0.9 servings/day) and vegetables (+1.3 servings/day) were all significantly increased in the LFHF group (all P<0.05). Serum levels of albumin, lutein and zeaxanthin, retinol, and retinyl palmitate were significantly increased in the FVJC group (all P<0.05). No changes in cancer antigen-125, anthropometry, or HRQOL were observed.

Conclusion: Overall, this study supports the feasibility of designing dietary interventions for stages II-IV ovarian cancer survivors and provides preliminary evidence that a low fat high fiber diet and a diet supplemented with encapsulated FVJC may increase phytonutrients in ovarian cancer survivors.

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Conflict of interest statement

Conflicts of Interest:

  1. Raheem Paxton, Celia Garcia-Prieto, Maria Berglund, Mike Hernandez, Richard A. Hejek, Beverly Handy, and Jubilee Brown declare that we have no conflicts of interest.

  2. Lovell A. Jones received funds from National Safety Associates (NSA; Collierville, TN) to conduct the research described in this manuscript.

Figures

Figure 1
Figure 1
CONSORT diagram.
Figure 2
Figure 2
One-way scatter plots were used to illustrate the range of change in serum carotenoid and α-tocopherol values for both intervention groups. Δ = change; LFHF=low fat, high fiber; FVJC=fruit and vegetable juice concentrate. All panels present data on a log-transformed scale, and dark lines represent the mean change.
See this image and copyright information in PMC

References

    1. Huncharek M, Kupelnick B. Dietary fat intake and risk of epithelial ovarian cancer: a meta-analysis of 6,689 subjects from 8 observational studies. Nutr Cancer. 2001;40:87–91. - PubMed
    1. Mulholland HG, Murray LJ, Cardwell CR, Cantwell MM. Dietary glycaemic index, glycaemic load and endometrial and ovarian cancer risk: a systematic review and meta-analysis. Br J Cancer. 2008;99:434–41. - PMC - PubMed
    1. Myung SK, Ju W, Choi HJ, Kim SC. Soy intake and risk of endocrine-related gynaecological cancer: a meta-analysis. BJOG. 2009;116:1697–705. - PubMed
    1. Genkinger JM, Hunter DJ, Spiegelman D, Anderson KE, Arslan A, Beeson WL, Buring JE, Fraser GE, Freudenheim JL, Goldbohm RA, Hankinson SE, Jacobs DR, Jr, Koushik A, Lacey JV, Jr, Larsson SC, Leitzmann M, McCullough ML, Miller AB, Rodriguez C, Rohan TE, Schouten LJ, Shore R, Smit E, Wolk A, Zhang SM, Smith-Warner SA. Dairy products and ovarian cancer: a pooled analysis of 12 cohort studies. Cancer Epidemiol Biomarkers Prev. 2006;15:364–72. - PubMed
    1. Kolahdooz F, Ibiebele TI, van der Pols JC, Webb PM. Dietary patterns and ovarian cancer risk. Am J Clin Nutr. 2009;89:297–304. - PubMed

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