Chance and necessity in the evolution of a bacterial pathogen
- PMID: 22120052
- DOI: 10.1038/ng.1011
Chance and necessity in the evolution of a bacterial pathogen
Abstract
The combination of genomic, epidemiological and evolutionary analyses provides a powerful toolbox for understanding how pathogens adapt to their human hosts. By sequencing 112 Burkholderia dolosa genomes from an outbreak among patients with cystic fibrosis, a new study documents evolution in action and identifies a set of genes that contributed to the pathogen's adaptation.
Comment on
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Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes.Nat Genet. 2011 Nov 13;43(12):1275-80. doi: 10.1038/ng.997. Nat Genet. 2011. PMID: 22081229 Free PMC article.
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