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Review
. 2011 Nov;33(11):1164-70.
doi: 10.3724/sp.j.1005.2011.01164.

[Advances on Drosophila presenilin gene]

[Article in Chinese]
Yu Zhang  1 , Zeng-Zhang Zheng, Jun Ge, Hong-Yan Zhang, Yan-Wang Huang, Hong-Sheng Song
Affiliations
Review

[Advances on Drosophila presenilin gene]

[Article in Chinese]
Yu Zhang et al. Yi Chuan. 2011 Nov.

Abstract

In Drosophila, presenilin is an aspartyl protease that plays important roles in the development and calcium homeostasis. It has been expressed all through the fly developmental process. The loss of Drosophila presenilin (DPS) function causes significantly decreased Notch signaling and neuron apoptosis and increased cytoplasm calcium. This subsequently led to impaired long term memory and cognitive deficits. Therefore, study of DPS is one of the most popular models for Alzheimer's disease research, and has provided important insights into the pathological mechanisms of AD. This review is to summarize the AD related function of DPS gene.

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