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. 2012 Apr 28;317(2):207-17.
doi: 10.1016/j.canlet.2011.11.026. Epub 2011 Nov 25.

Ovarian cancer: Stat3, RhoA and IGF-IR as therapeutic targets

Caroline Gest  1 , Pezhman Mirshahi, Hong Li, Linda-Louise Pritchard, Ulrich Joimel, Emmanuel Blot, Jean Chidiac, Bernard Poletto, Jean-Pierre Vannier, Remi Varin, Massoud Mirshahi, Lionel Cazin, Eric Pujade-Lauraine, Jeannette Soria, Claudine Soria
Affiliations

Ovarian cancer: Stat3, RhoA and IGF-IR as therapeutic targets

Caroline Gest et al. Cancer Lett. .

Abstract

Seeking to improve ovarian cancer therapy, we compared biological characteristics of the moderately-aggressive OVCAR-3 cell line with two highly aggressive ovarian cancer cell populations: the SK-OV-3 cell line, and HASCJ primary cells isolated from the ascitic fluid of a patient with FIGO stage IV ovarian cancer. Secretion of angiogenic factors was not discriminative, whereas cell invasion through Matrigel and vasculogenic mimicry were much greater in the more aggressive cells. Among 10 agents tested for their ability to decrease cancer cell aggressivity using these two models, inhibitors of Stat3, IGF-IR and Rho GTPase were found to be the most promising.

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