Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jan;40(Database issue):D841-6.
doi: 10.1093/nar/gkr1088. Epub 2011 Nov 24.

The IntAct molecular interaction database in 2012

Samuel Kerrien  1 , Bruno Aranda, Lionel Breuza, Alan Bridge, Fiona Broackes-Carter, Carol Chen, Margaret Duesbury, Marine Dumousseau, Marc Feuermann, Ursula Hinz, Christine Jandrasits, Rafael C Jimenez, Jyoti Khadake, Usha Mahadevan, Patrick Masson, Ivo Pedruzzi, Eric Pfeiffenberger, Pablo Porras, Arathi Raghunath, Bernd Roechert, Sandra Orchard, Henning Hermjakob
Affiliations

The IntAct molecular interaction database in 2012

Samuel Kerrien et al. Nucleic Acids Res. 2012 Jan.

Abstract

IntAct is an open-source, open data molecular interaction database populated by data either curated from the literature or from direct data depositions. Two levels of curation are now available within the database, with both IMEx-level annotation and less detailed MIMIx-compatible entries currently supported. As from September 2011, IntAct contains approximately 275,000 curated binary interaction evidences from over 5000 publications. The IntAct website has been improved to enhance the search process and in particular the graphical display of the results. New data download formats are also available, which will facilitate the inclusion of IntAct's data in the Semantic Web. IntAct is an active contributor to the IMEx consortium (http://www.imexconsortium.org). IntAct source code and data are freely available at http://www.ebi.ac.uk/intact.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Screen shot of the new editorial tool.
Figure 2.
Figure 2.
New graphical component showing a representation of experimental and biological features available on the enhanced IntAct website.
See this image and copyright information in PMC

References

    1. Kerrien S, Orchard S, Montecchi-Palazzi L, Aranda B, Quinn AF, Vinod N, Bader GD, Xenarios I, Wojcik J, Sherman D, et al. Broadening the horizon—level 2.5 of the HUPO-PSI format for molecular interactions. BMC Biol. 2007;5:44. - PMC - PubMed
    1. The UniProt Consortium. Ongoing and future developments at the Universal Protein Resource. Nucleic Acids Res. 2011;39:D214–D219. - PMC - PubMed
    1. Orchard S, Salwinski L, Kerrien S, Montecchi-Palazzi L, Oesterheld M, Stümpflen V, Ceol A, Chatr-aryamontri A, Armstrong J, Woollard P, et al. The minimum information required for reporting a molecular interaction experiment (MIMIx) Nat. Biotechnol. 2007;25:894–898. - PubMed
    1. de Matos P, Alcántara R, Dekker A, Ennis M, Hastings J, Haug K, Spiteri I, Turner S, Steinbeck C. Chemical entities of biological interest: an update. Nucleic Acids Res. 2010;38:D249–D254. - PMC - PubMed
    1. Cochrane G, Karsch-Mizrachi I, Nakamura Y, International Nucleotide Sequence Database Collaboration The International Nucleotide Sequence Database Collaboration. Nucleic Acids Res. 2011;39:D15–D18. - PMC - PubMed

Publication types