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Review
. 2012 May;166(2):420-33.
doi: 10.1111/j.1476-5381.2011.01796.x.

A-kinase anchoring proteins as potential drug targets

Jessica Tröger  1 , Marie C Moutty, Philipp Skroblin, Enno Klussmann
Affiliations
Review

A-kinase anchoring proteins as potential drug targets

Jessica Tröger et al. Br J Pharmacol. 2012 May.

Abstract

A-kinase anchoring proteins (AKAPs) crucially contribute to the spatial and temporal control of cellular signalling. They directly interact with a variety of protein binding partners and cellular constituents, thereby directing pools of signalling components to defined locales. In particular, AKAPs mediate compartmentalization of cAMP signalling. Alterations in AKAP expression and their interactions are associated with or cause diseases including chronic heart failure, various cancers and disorders of the immune system such as HIV. A number of cellular dysfunctions result from mutations of specific AKAPs. The link between malfunctions of single AKAP complexes and a disease makes AKAPs and their interactions interesting targets for the development of novel drugs. LINKED ARTICLES This article is part of a themed section on Novel cAMP Signalling Paradigms. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.166.issue-2.

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Figures

Figure 1
Figure 1
Distribution of AKAP-based scaffolding complexes. AKAPs target PKA and other signalling molecules to almost every cellular compartment. Some examples are shown in Figure 1. For details, see text.
See this image and copyright information in PMC

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