5-hydroxymethylcytosine, a modified mammalian DNA base with a potential regulatory role

Affiliations

Comment

Gerd P Pfeifer et al. Epigenomics. 2009 Oct.

. 2009 Oct;1(1):21-2.

doi: 10.2217/epi.09.18.

¹ Beckman Research Institute, City of Hope, Duarte, CA 91010, USA. gpfeifer@coh.org

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Comment on

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.
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The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain.
Kriaucionis S, Heintz N. Kriaucionis S, et al. Science. 2009 May 15;324(5929):929-30. doi: 10.1126/science.1169786. Epub 2009 Apr 16. Science. 2009. PMID: 19372393 Free PMC article.