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Review
. 2012;9(2):53-9.
doi: 10.1159/000333097. Epub 2011 Nov 26.

Using DNA methylation to understand biological consequences of genetic variability

Dena G Hernandez  1 , Andrew B Singleton
Affiliations
Review

Using DNA methylation to understand biological consequences of genetic variability

Dena G Hernandez et al. Neurodegener Dis. 2012.

Abstract

The advent of high-content genomic mapping technologies has provided numerous clues about the genetic architecture of complex disease and the tools with which to understand the biological framework resulting from this architecture. We believe that understanding and mapping epigenetic marks, in particular DNA methylation, which is suited to such assays, offers a timely opportunity in this context. Here, we make an argument for this work, describing this opportunity, the likely path ahead, and the problems and pitfalls associated with such work.

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