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. 2011 Nov 28;13(1):75.
doi: 10.1186/1532-429X-13-75.

Myocardial T1 and extracellular volume fraction mapping at 3 tesla

Jason J Lee  1 , Songtao Liu, Marcelo S Nacif, Martin Ugander, Jing Han, Nadine Kawel, Christopher T Sibley, Peter Kellman, Andrew E Arai, David A Bluemke
Affiliations

Myocardial T1 and extracellular volume fraction mapping at 3 tesla

Jason J Lee et al. J Cardiovasc Magn Reson. .

Abstract

Background: To compare 11 heartbeat (HB) and 17 HB modified lock locker inversion recovery (MOLLI) pulse sequence at 3T and to establish preliminary reference values for myocardial T1 and the extracellular volume fraction (ECV).

Methods: Both phantoms and normal volunteers were scanned at 3T using 11 HB and 17 HB MOLLI sequence with the following parameters: spatial resolution = 1.75 × 1.75 × 10 mm on a 256 × 180 matrix, TI initial = 110 ms, TI increment = 80 ms, flip angle = 35°, TR/TE = 1.9/1.0 ms. All volunteers were administered Gadolinium-DTPA (Magnevist, 0.15 mmol/kg), and multiple post-contrast MOLLI scans were performed at the same pre-contrast position from 3.5-23.5 minutes after a bolus contrast injection. Late gadolinium enhancement (LGE) images were also acquired 12-30 minutes after the gadolinium bolus.

Results: T1 values of 11 HB and 17 HB MOLLI displayed good agreement in both phantom and volunteers. The average pre-contrast myocardial and blood T1 was 1315 ± 39 ms and 2020 ± 129 ms, respectively. ECV was stable between 8.5 to 23.5 minutes post contrast with an average of 26.7 ± 1.0%.

Conclusion: The 11 HB MOLLI is a faster method for high-resolution myocardial T1 mapping at 3T. ECV fractions are stable over a wide time range after contrast administration.

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Figures

Figure 1
Figure 1
Phantom Study. 17 HB MOLLI sequences progressively underestimated T1 compared to IR-SE in phantoms as T1 and heart rate increased.
Figure 2
Figure 2
Phantom Study. 11 HB MOLLI sequences progressively underestimated T1 compared to IR-SE in phantoms as T1 and heart rate increased.
Figure 3
Figure 3
Phantom Study. Bland-Altman Plot comparing 17 HB MOLLI and 11 HB MOLLI T1 values at 60 bpm.
Figure 4
Figure 4
Human Study. Mid-ventricular short axis T1 maps. From left to right: pre-contrast, 5 minutes, 8.5 minutes, 13.5 minutes, 18.5 minutes and 23.5 minutes post-contrast. All images were displayed with same setting.
Figure 5
Figure 5
Human Study. Recovery of absolute myocardial and blood T1 from 3.5 minute to 23.5 minutes after 0.15 mmol/kg of Gd-DTPA.
Figure 6
Figure 6
Human Study. Average ECV fractions of post-contrast times for both 17 HB MOLLI and 11 HB MOLLI.
Figure 7
Figure 7
Human Study. Bland-Altman plot comparing all 17 HB MOLLI and 11 HB MOLLI ECV.
See this image and copyright information in PMC

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