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. 1979 May 15;35(5):575-6.
doi: 10.1007/BF01960326.

Increase of interferon antiviral activity by exogenous cyclic adenosine-3':5'-monophosphate (cAMP)

H Koblet, R Wyler, U Kohler

Increase of interferon antiviral activity by exogenous cyclic adenosine-3':5'-monophosphate (cAMP)

H Koblet et al. Experientia. .

Abstract

Some effects of cAMP on replication of Semliki Forest Virus in chick embryo fibroblast cell cultures are described. Depending on concentration, the incorporation of [3H]-uridine into viral RNA or the formation of plaque-forming units is inhibited; the highest concentration tested was 8 mM. Cyclic AMP has an effect of its own and increases the Interferon action in the lower concentration ranges of Interferon (up to 1 unit/ml). The effect of cyclic AMP is fast, needs no induction and is also visible in late phases of viral replication. However, these experiments do not establish a causal relation between cAMP and Interferon.

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References

    1. Virology. 1973 Nov;56(1):383-5 - PubMed
    1. Infect Immun. 1976 Feb;13(2):326-31 - PubMed
    1. Biochem Biophys Res Commun. 1969 Aug 22;36(5):735-40 - PubMed
    1. Experientia. 1976 Dec 15;32(12):1514-7 - PubMed
    1. Virology. 1963 Mar;19:302-9 - PubMed