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Comparative Study
. 2011 Dec;128(6):e1532-43.
doi: 10.1542/peds.2011-0245. Epub 2011 Nov 28.

Psychiatric and medical comorbidity and quality of life outcomes in childhood-onset epilepsy

Christine B Baca  1 , Barbara G Vickrey, Rochelle Caplan, Stefanie D Vassar, Anne T Berg
Affiliations
Comparative Study

Psychiatric and medical comorbidity and quality of life outcomes in childhood-onset epilepsy

Christine B Baca et al. Pediatrics. 2011 Dec.

Abstract

Objective: We compared associations of epilepsy remission status and severity as well as psychiatric and other comorbidities with child and parent-proxy reports of health-related quality of life (HRQoL) in adolescents previously diagnosed with epilepsy.

Methods: In a prospective, community-based study of newly diagnosed childhood epilepsy, HRQoL of 277 children was assessed 8 to 9 years after diagnosis by using child and parent-proxy versions of the Child Health Questionnaire (CHQ). Multiple linear regression models adjusted for age and gender were used to compare associations of epilepsy remission and "complicated" epilepsy (secondary to an underlying neurologic insult or epileptic encephalopathy) status and psychiatric and other comorbidities with HRQoL.

Results: Mean age of epilepsy onset was 4.4 years (SD: 2.6). At the 9-year reassessment, children were, on average, 13.0 years old (SD: 2.6); 64% were seizure-free for 5 years, 31% were taking antiepileptic drugs, and 19% had a complicated epilepsy. Prevalence of comorbidities at follow-up were 26% psychiatric diagnosis; 39% neurodevelopmental spectrum disorder (NDSD); 24% chronic medical illness; and 15% migraine. In multivariable analysis, having a psychiatric disorder was broadly associated with child (6 of 11 scales) and parent-proxy (7 of 12 scales) HRQoL (P ≤ .0125). Five-year remission and complicated epilepsy status had few or no associations with HRQoL. Although parent-proxy HRQoL was strongly associated with NDSD (6 of 11 scales), child-reported HRQoL was not (2 of 11 scales).

Conclusions: Psychiatric comorbidities are strongly associated with long-term HRQoL in childhood-onset epilepsy, which suggests that comprehensive epilepsy care must include screening and treatment for these conditions, even if seizures remit.

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Figures

FIGURE 1
FIGURE 1
Recruitment, follow-up, and sample selection.
FIGURE 2
FIGURE 2
Adjusted predicted HRQoL mean scale scores (± confidence intervals) calculated from multiple linear regression models for having versus not having a psychiatric comorbidity (A and B) and being seizure-free for 5 years or not (C and D). A, Child report: with psychiatric comorbidity versus without psychiatric comorbidity; B, parent-proxy report: with psychiatric comorbidity versus without psychiatric comorbidity; C, child report: seizure-free for 5 years versus not seizure-free for 5 years; D, parent-proxy report: seizure-free for 5 years versus not seizure-free for 5 years.
FIGURE 3
FIGURE 3
The association of NDSD with HRQoL in CWE (N = 277): differences in child and parent-proxy reports. Adjusted predicted HRQoL mean scale scores (± confidence intervals) were calculated from multiple linear regression models for having versus not having an NDSD: A, child-reported; B, parent-proxy report.
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