doi: 10.1039/c1cc16725a.
Epub 2011 Nov 28.
Copper(I) catalyzed asymmetric 1,2-addition of Grignard reagents to α-methyl substituted α,β-unsaturated ketones
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- PMID: 22124420
- DOI: 10.1039/c1cc16725a
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Copper(I) catalyzed asymmetric 1,2-addition of Grignard reagents to α-methyl substituted α,β-unsaturated ketones
Chem Commun (Camb).
.
Free article
Abstract
The first catalytic enantioselective 1,2-addition of Grignard reagents to ketones is presented. This additive-free copper(I) catalyzed 1,2-addition provides chiral allylic tertiary alcohols with an er of up to 98:2 and excellent yields due to the complete shift of overwhelming 1,4-selectivity of copper(I)-catalysts towards 1,2-selectivity in the addition reaction to enones.
This journal is © The Royal Society of Chemistry 2012
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