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. 2011 Dec;4(4):411-414.
doi: 10.1016/j.phytol.2011.04.016.

Chlorinated Withanolides from Withania somnifera

Xiaoqin Tong  1 , Huaping Zhang, Barbara N Timmermann
Affiliations

Chlorinated Withanolides from Withania somnifera

Xiaoqin Tong et al. Phytochem Lett. 2011 Dec.

Abstract

A chlorinated withanolide, 6α-chloro-5β,17α-dihydroxywithaferin A (1), and nine known withanolides, 6α-chloro-5β-hydroxywithaferin A (2), (22R)-5β-formyl-6β,27-dihydroxy-1-oxo-4-norwith-24-enolide, withaferin A, 2,3-dihydrowithaferin A, 3-methoxy-2,3-dihydrowithaferin A, 2,3-didehydrosomnifericin, withanone, withanoside IV and withanoside X, were isolated from Withania somnifera (Solanaceae). All structures were elucidated on the basis of spectroscopic methods (IR, HRESIMS, 1D/2D NMR). X-ray crystallography confirmed the absolute configuration of 1.

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Figures

Fig. 1
Fig. 1
Chlorinated withanolides from Withania somnifera.
Fig. 2
Fig. 2
Key HMBC correlations of compound 1.
Fig. 3
Fig. 3
ORTEP view of chlorinated withanolide 1.
See this image and copyright information in PMC

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