Effect of somatostatin on the potentiating action of glucagon, cyclic adenosine monophosphate and theophylline on glucose-induced insulin release
- PMID: 221281
Item in Clipboard
Effect of somatostatin on the potentiating action of glucagon, cyclic adenosine monophosphate and theophylline on glucose-induced insulin release
Diabete Metab.
1979 Mar.
Abstract
The effect of glucagon on the inhibition of the insulin response to glucose induced by somatostatin was investigated in humans and in the isolated perfused rat pancreas. Both in vivo and in vitro somatostatin suppressed glucose-induced insulin release. This inhibitory effect of somatostatin was overcome by glucagon. Similar results have been observed in vitro by the infusion of theophylline or cyclic adenosine monophosphate.
Similar articles
-
Studies on the mode of action of somatostatin on insulin secretion.Endocrinology. 1977 Nov;101(5):1436-43. doi: 10.1210/endo-101-5-1436. Endocrinology. 1977. PMID: 199419
-
Insulin secretion studied in the perfused rat pancreas. II. Effect of glucose, glucagon, 3'5' adenosine monophosphate, theophylline, imidazole and phenoxybenzamine; their interaction with diazoxide.Diabetes. 1971 Jul;20(7):457-66. doi: 10.2337/diab.20.7.457. Diabetes. 1971. PMID: 4397560 No abstract available.
-
Effect of theophylline on insulin, glucagon and somatostatin secretion from the isolated rat pancreatico-duodenal preparation.Endocrinol Jpn. 1981 Feb;28(1):9-16. doi: 10.1507/endocrj1954.28.9. Endocrinol Jpn. 1981. PMID: 6113955
-
Diazoxide and the secretion of insulin.Nutr Rev. 1972 Aug;30(8):194-8. doi: 10.1111/j.1753-4887.1972.tb04040.x. Nutr Rev. 1972. PMID: 4340200 Review. No abstract available.
-
Drugs and the mechanism of insulin secretion.Adv Pharmacol Chemother. 1969;7:91-115. Adv Pharmacol Chemother. 1969. PMID: 4315313 Review. No abstract available.
Cited by
-
Somatostatin and insulin secretion in man. II. The effect of theophylline.Acta Diabetol Lat. 1979 Oct-Dec;16(4):353-8. doi: 10.1007/BF02587656. Acta Diabetol Lat. 1979. PMID: 45065