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. 2012 Jan 12;55(1):291-6.
doi: 10.1021/jm201214d. Epub 2011 Dec 15.

Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine

Rachel D Slack  1 , Bryan T Mott, Lauren E Woodard, Abhai Tripathi, David Sullivan, Elizabeth Nenortas, Sonya C T Girdwood, Theresa A Shapiro, Gary H Posner
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Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine

Rachel D Slack et al. J Med Chem. .

Erratum in

  • J Med Chem. 2012 Feb 23;55(4):1788. Triphati, Abhai [corrected to Tripathi, Abhai]

Abstract

Sixteen new anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial efficacy in Plasmodium berghei infected mice. Of these 16 new anilides administered orally as one 6 mg/kg dose combined with 18 mg/kg mefloquine hydrochloride, only sulfide 3-arteSanilide 12d was completely curative: on day 30 after infection, all mice in this group had no detectable parasitemia, gained as much weight as the uninfected control mice, and behaved normally.

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