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Review
. 2012 Feb 1;4(2):a011593.
doi: 10.1101/cshperspect.a011593.

mTOR Signaling

Mathieu Laplante  1 , David M Sabatini
Affiliations
Review

mTOR Signaling

Mathieu Laplante et al. Cold Spring Harb Perspect Biol. .

Abstract

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that integrates environmental cues (e.g., growth factors and energy status) to control cell growth and proliferation.

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Figures

Figure 1.
Figure 1.
A simplified view of the mTOR pathway. (Adapted from Laplante and Sabatini 2009b.)
Figure 2.
Figure 2.
The mTOR pathway.
See this image and copyright information in PMC

References

    1. Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS, Schreiber SL 1994. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369: 756–758 - PubMed
    1. Heitman J, Movva NR, Hall MN 1991. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253: 905–909 - PubMed
    1. Kunz J, Henriquez R, Schneider U, Deuter-Reinhard M, Movva NR, Hall MN 1993. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell 73: 585–596 - PubMed
    1. Laplante M, Sabatini DM 2009a. An emerging role of mTOR in lipid biosynthesis. Curr Biol 19: R1046–R1052 - PMC - PubMed
    1. Laplante M, Sabatini DM 2009b. mTOR signaling at a glance. J Cell Sci 122: 3589–3594 - PMC - PubMed

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