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Comment
. 2012 Mar;129(3):867-9.
doi: 10.1016/j.jaci.2011.10.021. Epub 2011 Nov 30.

Decreased expression of acetaminophen-metabolizing enzymes and glutathione in asthmatic children after acetaminophen exposure

Susan T Stephenson, Graham Hadley, Lou Ann S Brown, Anne M Fitzpatrick
Comment

Decreased expression of acetaminophen-metabolizing enzymes and glutathione in asthmatic children after acetaminophen exposure

Susan T Stephenson et al. J Allergy Clin Immunol. 2012 Mar.

Abstract

Children with moderate-to-severe asthma have decreased expression of acetaminophen metabolizing genes and glutathione that may account for the previously-reported risk of acetaminophen in this vulnerable population.

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Figures

Figure 1
Figure 1
mRNA expression of (A) AHR, (B) ARNT, and (C) ASNA1 in healthy adult controls (AC) and children with moderate-to-severe asthma after 15 µg/mL acetaminophen (APAP) exposure. Baseline expression data from age-matched, atopic pediatric controls (PC) are also shown for comparison.
See this image and copyright information in PMC

Comment on

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