doi: 10.1002/ptr.3663.
Epub 2011 Dec 1.
Lignans with anti-hepatitis B virus activities from Phyllanthus niruri L
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- PMID: 22131154
- DOI: 10.1002/ptr.3663
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Lignans with anti-hepatitis B virus activities from Phyllanthus niruri L
Phytother Res.
2012 Jul.
Abstract
One new lignan, nirtetralin B, along with its two known stereoisomers were isolated from Phyllanthus niruri L. The structure of the new compound was determined by spectroscopy experiments and x-ray diffraction analysis. These lignans were assayed for anti-hepatitis B virus activities in vitro. Nirtetralin and nirtetralin A, B effectively suppressed the secretion of the HBV antigens in a dose-dependent manner with IC₅₀ values for HBsAg of 9.5 µM (nirtetralin A), 16.7 µM (nirtetralin B) and 97.2 µM (nirtetralin), IC₅₀ values for HBeAg of 17.4 µM (nirtetralin A), 69.3 µM (nirtetralin B) and 232.0 µM (nirtetralin), respectively.
Copyright © 2011 John Wiley & Sons, Ltd.
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